Upneeq

What is UPNEEQ?

UPNEEQ-(oxymetazoline hydrochloride ophthalmic solution), al% is a prescription eyed rop used to treat low-lying lids (acquired blepharoptosis) in adults.

What warnings and precautions are associated with UPNEEQ?

Low-lying lids may be related to conditions such as stroke and/or brain aneurysm, Horner syndrome, myasthenia gravis, loss of the ability to move eye muscles, eye infection, and eye tumors. Ask your doctor if you have any of these conditions.

Take a look in the mirror. What do you see?* 

If you are bothered by your eyelid(s), talk to your healthcare provider to find out whether or not you have low-lying lids.

*This is for preliminary assessment only. Your healthcare provider can perform specific tests to accurately diagnose your type of low-lying lids. 

You may have acquired ptosis. Acquired ptosis (low-lying lids) is a common condition that:

• Affects adults of all ages, but occurs more often with increased age
• Usually occurs when the muscles in the eyelid stretch and weaken, causing the lid to droop
• May be caused by other issues, such as cataract surgery, contact lens wear, or an underlying medical condition.

How does acquired ptosis affect you?

In addition to affecting your appearance, low-lying eyelid (s) can also impact your eyesight by reducing your field of vision. Low-lying lids may lead to issues with: 

• Day-to-day functioning
  • Reading
  • Driving
  • Computer use 
• Appearance
  • Looking tired
  • Asymmetrical eyes
  • Cosmetic concerns 

What are the most common side effects of UPNEEQ (oxymetazoline hydrochloride ophthalmic solution), 0.1%?

The most common adverse reactions with UPNEEQ (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.

What should my doctor know about before prescribing me UPNEEQ?

• Your doctor should review your full medical history before prescribing UPNEEQ.
• UPNEEQ belongs to a class of medication (alphaadrenergic agonists) that may affect your blood pressure. Use UPNEEQ carefully if you currently take an alphaadrenergic antagonist medication to treat heart disease or an enlarged prostate. Patients taking beta-blockers, or other medications to treat hypertension or an abnormal heartbeat, should also be careful when using UPNEEQ.
• Patients who use a certain class of antidepressant medication (monoamine oxidase inhibitors) should also be careful when using UPNEEQ, as it may affect the way your body absorbs the medication. 

Significantly improves upper field of vision

In clinical trials, Upneeq helped patients with acquired ptosis see more—on the first day of treatment!

• 87.8% of patients had some level of improvement
• 40.8% of patients had at least a 50% improvement on Day14 (2 hours after applying Upneeq) 

WHAT CAN UPNEEQ DO FOR YOU?

Lifts eyelid(s) quickly

• Most patients in clinical trials had a lift in their eyelids in as little as 2 hours
  • 84% of patients had some level of improvement
  • 74% of patients had more than a 50% improvement
• In one study, some patients saw a lift in their eyelids as fast as 5 minutes after the first dose.

Upneeq is also safe and well-tolerated

In clinical trials, Upneeq was proven to be safe and effective when used as directed Common side effects (seen in 1-5% of patients) included eye inflammation, eye redness, dry eye, blurred vision, instillation site pain, eye irritation, and headache.

IMPORTANT SAFETY INFORMATION:

These are not all of the possible side effects of UPNEEQ. Tell your doctor if you have any side effect that bothers you or does not go away. Call your doctor for medical advice about side effects. To report side effects or product complaints, contact RVL Pharmaceuticals at 1-877-482-3788. You may also report side effects to the FDA by calling 1-800-FDA-1088 or visit www.fda.gov/medwatch. This document has summarized the most important safety information for UPNEEQ. For more in-depth safety information, please review the full Prescribing Information for UPNEEQ. 

What warnings and precautions are associated with UPNEEQ?

• UPNEEQ is a type of medication that may affect your blood pressure. If you have heart disease, uncontrolled high or low blood pressure, or feel faint at rest or when quickly standing up, you should call your doctor if your symptoms get worse.
• Patients with reduced blood flow to the brain or heart, or patients who experience eye or mouth dryness due to an immune system disorder (Sjogren's syndrome), should use care when taking UPNEEQ. Call your doctor immediately if you feel your symptoms may be getting worse. 
• UPNEEQ may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using UPNEEQ.
• Do not let the tip of the UPNEEQ vial touch your eye or any other surface. This can help prevent eye injury or contamination. Each UPNEEQ vial is for one-time use and should be discarded after being used.